Nick Bosa's six-week holdout is now over after the San Francisco 49ers and the 2022 NFL Defensive Player of the Year agreed to a reported five-year, $170 million extension that will make him the highest-paid defensive player in league history.

NFL.com reported Wednesday that Bosa will receive $122.5 million in guaranteed money and the 49ers will waive all fines the star edge rusher incurred by missing all of training camp and the preseason.

The deal is the largest ever for a defensive player in terms of both average annual value and guaranteed money. Los Angeles Rams defensive tackle Aaron Donald had the largest AAV at $31.7 million while Bosa's brother, Joey, received a then-record $102 million in guarantees on his 2020 extension with the Los Angeles Chargers. 

The two sides were able to strike a deal four days before the 49ers' season opener against the Pittsburgh Steelers on Sunday, a game head coach Kyle Shanahan said Bosa may now be able to participate in to some degree.

"We've got to see when he gets here," Shanahan told reporters Wednesday on Bosa's availability for Week 1. "I know Nick will come in shape, I know he'll be good. 

"We'll be smart with it and it will be based on these next two-and-a-half practices."

BREAKING: 49ers, DE Nick Bosa agree to terms on 5-year, $170M contract extension. (via @RapSheet) pic.twitter.com/LT34AgbeOT

— NFL (@NFL) September 6, 2023

Bosa was a runaway winner of last season's Defensive Player of the Year award after amassing a league-best 18.5 sacks, 19 tackles for loss and 48 quarterback hurries in 16 games. The 25-year-old was entering the final season of his five-year, $51.4 million rookie contract.

Taken by the 49ers with the second overall pick of the 2019 draft, Bosa has recorded 43 sacks, 56 tackles for loss and one interception in 51 career regular-season games as a lynchpin of a stout San Francisco defence that has helped the franchise reach the NFC Championship Game in three of his four seasons.

Bosa missed most of the 2020 season after tearing his ACL in the 49ers' second game, but returned with a banner 2021 campaign in which he registered 15.5 sacks during the regular season and four more in three postseason games.