Tane Edmed has been given the nod at fly-half for Australia against England, with Joseph-Aukuso Sua'ali'i, Max Jorgensen and Taniela Tupou all recalled.

Edmed has only previously started three Tests, but is picked with Carter Gordon not included in the squad as he is believed to be struggling with a quad strain.

Sua'ali'i impressed on his Test debut at Twickenham last year and will be partnered by Hunter Paisami at centre.

Tupou will make his first appearance since the defeat to New Zealand in September, making up a powerful back row, which also includes Harry Wilson, Rob Valetini and Fraser McReight.

Australia are still without several European-based players, though, including James O'Connor, Will Skelton and Len Ikitau, due to this fixture falling outside of the official international window.

Nick Champion de Crespigny, who was stand-in captain for the win over Japan last week, is among the replacements, as is Hamish Stewart.

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"The coaches have tried to balance this year's tough schedule in terms of Test matches and travel," said head coach Joe Schmidt.

"It was great to freshen a few players up last weekend, and we hope that allows the group to be really competitive on Saturday."

Overall, England have 28 Test wins over Australia, compared to 27 victories for the Wallabies (D1).

However, Australia have lost 10 of the team's last 12 meetings dating back to June 2016, though the Wallabies did secure a memorable 42-37 win when the sides last met at Twickenham.

Australia XV: Andrew Kellaway; Max Jorgensen, Joseph-Aukuno Sua'ali'i, Hunter Paisami, Harry Potter; Tane Edmed, Jake Gordon; Angus Bell, Billy Pollard, Taniela Tupuo, Nick Frost, Jeremy Williams, Rob Valentini, Fraser McReight, Harry Wilson (captain).

Replacements: Josh Nasser, Tom Robertson, Allan Alaalatoa, Lukhan Salakaia-Loto, Nick Champion de Crespigny, Ryan Lonergan, Hamish Stewart, Filipo Daugunu.